Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation. we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region. between residues R87 and T88. https://www.chiggate.com/dog-in-car-for-discount/