Abstract Background Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational spectrum. In addition to the implementation of multiple pieces of evidence for the classification of gene variants. POLE and POLD1 variant ... https://www.jmannino.com/special-deal-A-Magazine-Curated-By-Sacai-quick-pick/