Abstract Replication of vertebrate genomes is tightly regulated to ensure accurate duplication. but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here. we investigated the involvement of three elements enriched at gene promoters and replication origins: guanine-rich motifs potentially forming G-quadruplexes (pG4s). https://ashleyshomestores.shop/product-category/5-piece-twin-sleigh-bedroom/